Operant social self-administration in male CD1 mice.

ABSTRACT:

Rationale and objective

We recently introduced a model of operant social reward in which female CD1 mice lever press for access to affiliative social interaction with a cagemate peer mouse of the same sex and strain. Here we determined the generality of the operant social self-administration model to male CD1 mice who, under certain conditions, will lever press to attack a subordinate male mouse.

Methods

We trained male CD1 mice to lever press for food and social interaction with a same sex and strain cagemate peer under different fixed-ratio (FR) schedule response requirements (FR1 to FR6). We then tested their motivation to seek social interaction after 15 days of isolation in the presence of cues previously paired with social self-administration. We also determined the ef

SUBMITTER: Lee SS 

PROVIDER: S-EPMC11895805 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature