Left ventricular fibrosis and CMR tissue characterization of papillary muscles in mitral valve prolapse patients.

ABSTRACT:

Purpose

Mitral valve prolapse (MVP) is associated with left ventricle (LV) fibrosis, including the papillary muscles (PM), which is in turn linked to malignant arrhythmias. This study aims to evaluate comprehensive tissue characterization of the PM by cardiovascular magnetic resonance (CMR) imaging and its association with LV fibrosis observed by intraoperative biopsies.

Methods

MVP patients with indication for surgery due to severe mitral regurgitation (n = 19) underwent a preoperative CMR with characterization of the PM: dark-appearance on cine, T1 mapping, conventional bright blood (BB) and dark blood (DB) late gadolinium enhancement (LGE). CMR T1 mapping was performed on 21 healthy volunteers as controls. LV inferobasal myocardial biopsies were obtained in MVP patients a

SUBMITTER: Spampinato RA 

PROVIDER: S-EPMC11895843 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature