Characterizing oxidative stress induced by Aβ oligomers and the protective role of carnosine in primary mixed glia cultures.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and memory loss. A critical aspect of AD pathology is represented by oxidative stress, which significantly contributes to neuronal damage and death. Microglia and astrocytes, the primary glial cells in the brain, are crucial for managing oxidative stress and supporting neuronal function. Carnosine is an endogenous dipeptide possessing a multimodal mechanism of action that includes antioxidant, anti-inflammatory, and anti-aggregant activities. The present study investigated the effects of Aβ1-42 oligomers (oAβ), small aggregates associated with the neurodegeneration observed in AD, on primary rat mixed glia cultures composed of both microglia and astrocytes, focusing on the ability of these detriment

SUBMITTER: Cardaci V 

PROVIDER: S-EPMC11895860 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature