Characterizing the genetic diversity and population structure of Plasmodium knowlesi in Aceh Province, Indonesia.

ABSTRACT: As in other parts of Southeast Asia, efforts to achieve or sustain malaria elimination in Indonesia have been threatened by the emergence of human infection with the primate species P. knowlesi. To understand the transmission dynamics of this species, investigation of P. knowlesi genetic diversity and population structure is needed. A molecular surveillance study was conducted in two phases between June 2014 and September 2018 at five primary health facilities in Aceh Province, Indonesia, an area nearing malaria elimination. Dried blood spot samples were collected from patients presenting with suspected malaria and testing positive for malaria by microscopy. PCR was performed for molecular confirmation and species identification. Forty-six samples were confirmed to be P. knowlesi, of which

SUBMITTER: Kariodimedjo PP 

PROVIDER: S-EPMC11896071 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature