Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration.

ABSTRACT: The conserved MAP3K12/Dual Leucine Zipper Kinase (DLK) plays versatile roles in neuronal development, axon injury and stress responses, and neurodegeneration, depending on cell-type and cellular contexts. Emerging evidence implicates abnormal DLK signaling in several neurodegenerative diseases. However, our understanding of the DLK-dependent gene network in the central nervous system remains limited. Here, we investigated the roles of DLK in hippocampal glutamatergic neurons using conditional knockout and induced overexpression mice. We found that dorsal CA1 and dentate gyrus neurons are vulnerable to elevated expression of DLK, while CA3 neurons appear less vulnerable. We identified the DLK-dependent translatome that includes conserved molecular signatures and displays cell-type specifici

SUBMITTER: Ritchie EM 

PROVIDER: S-EPMC11896613 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature