Ovarian function in adolescents and young adults undergoing cancer treatment: biochemical and ultrasound marker analysis.

ABSTRACT:

Objective

Gonadal dysfunction is a major late complication after cancer diagnosis and treatment. We aimed to study the prevalence of premature ovarian insufficiency (POI) and the potential reduction of ovarian reserve in a cohort of adolescent and young adult (AYA) patients undergoing cancer treatments, evaluating ovarian function and reserve markers. We also aimed to analyze how these markers are related to each other and to treatment-related risk factors.

Methods

We performed a retrospective study, including all female AYA patients undergoing cancer treatment during childhood or adolescence, who visited our pediatric gynecology outpatient clinic between January 1, 2018, and August 30, 2023. Serum levels of anti-Mullerian hormone (AMH) and follicle-stimulating hormone (FSH)

SUBMITTER: Signorino C 

PROVIDER: S-EPMC11896650 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature