Murine gut microbial interactions exert antihyperglycemic effects.

ABSTRACT: The correlations between gut microbiota and host metabolism have been studied extensively, whereas little relevant work has been done to investigate the impact of gut microbial interactions on host metabolism. With the use of a bacteriocin-targeting strategy, we aimed to identify the gut microbes associated with glucose and lipid metabolism by adjusting the gut microbial composition of mice fed a high-fat diet. To fulfill this goal, a Listeria monocytogenes (Lmo)-derived bacteriocin Lmo2776 secretion module was constructed and integrated into the genome of Escherichia coli Nissle 1917 (EcN), yielding the Lmo2776-secreting strain EcN-2776. In high-fat diet-fed mice, EcN-2776 administration decreased blood glucose and increased serum triglyceride, and gene amplicon sequencing of 16S rRNA in

SUBMITTER: Guo L 

PROVIDER: S-EPMC11896791 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature