Development of Miniprotein-Type Inhibitors of Biofilm Formation in <i>Candida albicans</i> and <i>Candida auris</i>.

ABSTRACT: Candida auris is a pathogenic fungus associated with high-mortality infections and forms resilient biofilms on various surfaces. In this study, we introduced a novel antifungal strategy against C. auris by integrating an AI-powered protein design tool, ProteinMPNN, with classical molecular dynamics (MD) simulations to design artificial proteins from a miniprotein library. This combined approach accelerated and enhanced the design process, enabling the rapid development of effective miniprotein inhibitors specifically targeting C. auris biofilm formation. The miniproteins developed in this study exhibited potent inhibitory effects on C. auris biofilms, representing a significant advancement in antifungal therapy. Notably, the combined application of these minipro

SUBMITTER: Kim D 

PROVIDER: S-EPMC11896806 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature