Impact of <i>Ligilactobacillus salivarius</i> Li01 on benzo[<i>a</i>]pyrene-induced colitis, based on host-microbiome interactions in Mongolian gerbils.

ABSTRACT:

Background

Probiotics supplementations have been regarded as an effective strategy for colitis treatment. However, the effect of Ligilactobacillus salivarius Li01 on benzo[a]pyrene (BaP)-induced colitis in Mongolian gerbils remains unclear. In this study, we leverage a BaP-induced model of colitis that exhibits significant remission following Ligilactobacillus salivarius Li01 intervention, to conduct an animal experiment that integrates histopathological assessment, inflammatory cytokines, 16S rRNA sequencing, targeted metabolomic profiling to investigate the relationship between Ligilactobacillus salivarius Li01, gut microbiota, and colitis.

Results

We demonstrated that the improvements in colon histopathological assessment and inflammatory cytok

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11896860 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature