Identifying potential biomarkers and molecular mechanisms related to arachidonic acid metabolism in vitiligo.

ABSTRACT:

Background

Numerous studies have reported that dysregulation of fatty acid metabolic pathways is associated with the pathogenesis of vitiligo, in which arachidonic acid metabolism (AAM) plays an important role. However, the molecular mechanisms of AAM in the pathogenesis of vitiligo have not been clarified. Therefore, we aimed to identify the biomarkers and molecular mechanisms associated with AAM in vitiligo using bioinformatics methods.

Methods

The GSE75819 and GSE65127 datasets were used in this study as the training and validation sets, respectively, along with 58 AAM-related genes (AAM-RGs). The differentially expressed genes (DEGs) between the lesional and control groups in the training set were identified through differential expression analysis. A biomarker-based nom

SUBMITTER: Li X 

PROVIDER: S-EPMC11896865 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature