Quantitative MRI for Monitoring Metabolic Dysfunction-Associated Steatotic Liver Disease: A Test-Retest Repeatability Study.

ABSTRACT:

Background

Quantitative magnetic resonance imaging metrics iron-corrected T1 (cT1) and liver fat from proton density fat-fraction (PDFF) are both commonly used as noninvasive biomarkers for metabolic dysfunction-associated steatohepatitis (MASH); however, their repeatability in this population has rarely been characterized.

Purpose

To quantify the variability of cT1 and liver fat fraction from PDFF in patients with biopsy-confirmed metabolic dysfunction-associated steatotic liver disease (MASLD) and MASH.

Study type

Prospective, single center.

Population

Twenty-one participants (female = 11, mean age 53 ± 24 years) with biopsy-confirmed MASLD, including 6 with MASH and fibrosis ≥2.

Field strength/sequence

3 T; T1 and T2* mapping for the generation of cT1

SUBMITTER: Beyer C 

PROVIDER: S-EPMC11896917 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature