Longitudinal Multiparametric Quantitative MRI Evaluation of Acute and Chronic Multiple Sclerosis Paramagnetic Rim Lesions.

ABSTRACT:

Background

Multiple sclerosis (MS) paramagnetic rim lesions (PRLs) are markers of chronic active biology and exhibit complex iron and myelin changes that may complicate quantification when using conventional MRI approaches.

Purpose

To conduct a multiparametric MRI analysis of PRLs.

Study type

Retrospective/longitudinal.

Subjects

Ninety-five progressive MS subjects with at least one persistent PRL who were enrolled in the CONSONANCE trial.

Field strength/sequence

3-T/Susceptibility-weighted, T1-weighted, T2-weighted, and fluid-attenuated inversion recovery.

Assessment

Acute/chronic PRLs and non-PRLs were measured at screening, 24, 48, and 96 weeks using quantitative magnetic susceptibility (QS), R2*, and standardized T1w/T2w ratio (sT1w/T2w). PRL a

SUBMITTER: Elkady AM 

PROVIDER: S-EPMC11896925 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature