Quantifying Spatial Distribution of Ventilation Defects in Multiple Pulmonary Diseases With Hyperpolarized ¹²⁹Xenon MRI.

ABSTRACT:

Background

Hyperpolarized ¹²⁹Xe MRI assesses lung ventilation, often using the ventilation defect percentage (VDP). Unlike VDP, defect distribution index (DDI) quantifies spatial clustering of defects.

Purpose

To quantify spatial distribution of ¹²⁹Xe ventilation defects using DDI across pulmonary diseases.

Study type

Retrospective.

Subjects

Four hundred twenty-one subjects (age = 23.1 ± 17.1, female = 230), comprising healthy controls (N = 60) and subjects with obstructive conditions (asthma [N = 25], bronchiolitis obliterans syndrome [BOS, N = 18], cystic fibrosis [CF, N = 90], lymphangioleiomyomatosis [LAM, N = 50]), restrictive conditions (bleomycin-treated cancer survivors [BLEO, N = 14]; fibrotic lung diseases [FLD, N = 92]), bone ma

SUBMITTER: Bdaiwi AS 

PROVIDER: S-EPMC11896935 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature