RBIS as a prognostic biomarker for progression-free survival in prostate cancer: insights from bioinformatics and immune infiltration analysis.

ABSTRACT:

Background

Prostate cancer (PCa) is a highly prevalent malignancy among men, with significant regional variations in incidence and poor survival rates in advanced stages. Ribosome biogenesis (RB) is pivotal for cancer cell proliferation, yet the specific role of the ribosomal biogenesis factor (RBIS) gene in PCa remains underexplored. This study aims to elucidate the biological and clinical relevance of RBIS in PCa progression.

Methods

We analyzed RNA-sequencing data from the TCGA database and three GEO datasets to compare RBIS expression in normal versus tumor tissues. The relationship between RBIS expression and clinicopathological features, including tumor stage, Gleason score, and progression-free survival (PFS), was assessed. Co-expression and functional enrichment anal

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11896948 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature