The causal relationship between eosinophil counts and hepatocellular carcinoma in East Asians: evidence from a Mendelian randomization study.

ABSTRACT:

Objectives

To investigate the causal relationship between the genetically predicted eosinophil counts and hepatocellular carcinoma (HCC) in East Asians. Additionally, we aimed to explore the infiltration and clinical impact of eosinophils in HCC using the Gene Expression Profiling Interactive Analysis (GEPIA).

Methods

We utilized a discovery set to explore the correlation between eosinophil counts and HCC, and validated the findings using a validation set. We employed multivariate mendelian randomization (MR) analysis to exclude confounding factors. The results from the discovery set and the validation set were combined through meta-analysis. The GEPIA online platform was utilized to analyze the infiltration and clinical impact of eosinophils in HCC.

Results

The genet

SUBMITTER: Liu D 

PROVIDER: S-EPMC11896953 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature