Population Genetic Structure and Human Adaptation of Kaposi Sarcoma-Associated Herpesvirus.

ABSTRACT:

Background

Kaposi sarcoma-associated herpesvirus (KSHV), the etiologic agent of Kaposi sarcoma, is human-specific and is thought to have emerged from primate-infecting gammaherpesviruses. KSHV seroprevalence shows geographic variation, being highest in sub-Saharan Africa, intermediate in the Mediterranean area, and low in most other locations. However, KSHV prevalence is also particularly high in specific regions such as the Miyako Islands (Japan).

Methods

We retrieved KSHV genomes from public repositories and analyzed geographic patterns using principal component analysis and STRUCTURE. Adaptation to the human host was investigated by likelihood ratio tests for positive selection. Protein structures were derived from the HerpesFolds database.

Results

Most non-African

SUBMITTER: Mozzi A 

PROVIDER: S-EPMC11896972 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature