Defining optimal electrospun membranes to enhance biological activities of human endometrial MSCs.

ABSTRACT:

Introduction

Human endometrial mesenchymal stem cells (H-EMSCs) can inhibit endometrial fibrosis and repair damaged endometrium. However, direct cell injection into dam-aged endometrium shows limited cell survival. Cell seeding onto biomaterial-based electrospun membranes could improve H-EMSCs' survival and prolong their stay at the damaged endometrium. Polycaprolactone (PCL), silk fibroin (SF) and hyaluronic acid (HA) are synthetic or natural biomaterials used by the biomedicine field, however, their effects on the biological activities of H-EMSCs remain unclear.

Methods

In this study, CD90⁺CD73⁺CD45^- H-EMSCs were extracted from human endometrium and H-EMSCs showed enhanced adhesion, proliferation on PCL-HA vs. PCL, PCL-SF, establishing the

SUBMITTER: An J 

PROVIDER: S-EPMC11896994 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature