High prevalence of carbapenem-resistant <i>Pseudomonas aeruginosa</i> and identification of a novel VIM-type metallo-β-lactamase, VIM-92, in clinical isolates from northern China.

ABSTRACT: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) has become a serious global health concern due to the limited treatment options. The primary resistance mechanism in CRPA involves the production of metallo-β-lactamases (MBLs), making MBL-producing P. aeruginosa a significant component of CRPA cases. To understand the prevalence of CRPA in hospitals in northern China, we conducted a preliminary screening and identification of CRPA in 143 clinical isolates of P. aeruginosa collected from various departments of a tertiary hospital between 2021 and 2023, analyzing CRPA resistance trends in certain regions of northern China during this period. We identified 71 CRPA isolates that exhibited high carbapenem resistance and phylogenetic tree analysis revealed that ST244 CRPA i

SUBMITTER: Zhao L 

PROVIDER: S-EPMC11897005 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature