Integrative analysis of DNA methylation and gene expression in skin cutaneous melanoma by bioinformatic approaches.

ABSTRACT: Skin cutaneous melanoma represents a significant threat among skin cancers. Investigating key methylated genes with prognostic implications remains an area ripe for exploration in this field. This study aims to identify survival-associated methylated genes and their specific methylation sites in skin cutaneous melanoma through integrated bioinformatic analysis. Utilizing data from the Cancer Genome Atlas database, gene methylation and expression files were analyzed. The results indicate that patients with skin cutaneous melanoma exhibiting high expression of hypomethylated HHEX experience better outcomes compared to those with low expression of hypermethylated HHEX. Furthermore, fifteen methylation sites within HHEX were found to significantly correlate with its expression levels. Expressi

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11897118 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature