Population-specific patterns in assessing molecular subtypes of young black females with triple-negative breast cancer.

ABSTRACT: We determined triple-negative breast cancer (TNBC) subtypes, genetic ancestry, and immune features in a cohort of self-reported Black females with TNBC diagnosed at or below age 50. Among 104 tumors, 34.6% were basal-like 1 (BL1), 17.3% basal-like 2 (BL2), 9.6% luminal androgen receptor (LAR), 26.9% mesenchymal (M), and 11.5% unsubtyped (UNS). Subtypes resembled those seen in Europeans or East Asians, with less LAR (9.6% vs. 14.6-24.4%) and more UNS (11.5% vs. 0-7.5%). "High" proportion of West African ancestry was associated with more LAR (14.9% vs. 4.9%) and less M (25.5% vs. 34.2%). M demonstrated reduced immune activity and was marginally associated with worse overall survival in a multivariate model including stage, West African ancestry, BMI, and TILs, meriting future research. Our s

SUBMITTER: Rajagopal PS 

PROVIDER: S-EPMC11897140 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature