Brain Perfusion, Atrophy, and Dopaminergic Changes in Amyloid Negative Logopenic Primary Progressive Aphasia.

ABSTRACT: Although most cases of logopenic variant primary progressive aphasia (lvPPA) are caused by Alzheimer's disease (AD), Lewy body disease (LBD) has also been reported. We assessed brain perfusion, atrophy, dopamine transporter (DAT) uptake, and language function among patients with lvPPA based on beta-amyloid. Thirty-three patients with lvPPA and 28 healthy controls (HCs) underwent MRI, ¹⁸F-florbetaben PET, and early- and late-phase DAT PET. All patients completed a language test. General linear models were applied to investigate the association of brain imaging with the aphasia quotient (AQ) and repetition scores. 20 (60.6%) and 13 (39.4%) of the lvPPA patients were amyloid-positive (lvPPA^A+) and -negative (lvPPA^A-), respectively. Language function was compar

SUBMITTER: Kang S 

PROVIDER: S-EPMC11897146 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature