Phenotype and genotype of carbapenem-resistant hypervirulent <i>Klebsiella pneumoniae</i> in a teaching hospital in Shanghai, China.

ABSTRACT: Introduction. Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is an emerging pathogen associated with severe clinical outcomes, prompting an urgent investigation into its genomic characteristics and pathogenic potential.Hypothesis/Gap Statement. We hypothesize that CR-hvKP strains exhibit high-level resistance and high virulence, leading to their rapid spread in clinical settings and posing a serious threat to clinical treatment.Aim. The aim of the study was to investigate the phenotype and genotype of CR-hvKP strains, reveal their resistance- and virulence-related genomic characteristics and elucidate the biological characteristics of high-virulence and high-resistance strains to provide molecular epidemiological data for clinical use.Meth

SUBMITTER: Ma W 

PROVIDER: S-EPMC11897171 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature