Drug-associated gingival disorders: a retrospective pharmacovigilance assessment using disproportionality analysis.

ABSTRACT:

Background

Drug-associated gingival disorders can negatively impact on oral health. This study aimed to utilize the United States Food and Drug Administration Adverse Event Reporting System (USFDA AERS) to comprehensively assess the associations between medications and specific gingival disorders.

Methods

Data were extracted from the USFDA AERS from 2004-2024 using Preferred Terms for eight gingival disorders. Reports were deduplicated and disproportionality analysis was conducted using frequentist and Bayesian approaches to detect potential signals. Volcano plots were generated for each gum disorder to identify the drugs with the strongest signals based on the statistical significance and magnitude of association.

Results

A total of 11,465 reports were included. Seve

SUBMITTER: Sridharan K 

PROVIDER: S-EPMC11897221 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature