Designing polymersomes with surface-integrated nanoparticles through hierarchical phase separation.

ABSTRACT: Polymersomes with surface-integrated nanoparticles, in which a smaller sphere is attached to a larger capsule, are typically formed through complex processes like membrane deformation, polymerization, or membrane functionalization. This complexity restricts facile application of this unusual topology, for example in drug delivery or nanomotor science. Our study introduces a robust method for crafting polymersomes with surface-integrated nanoparticles using a hierarchical phase separation approach. By co-assembling block copolymers with aromatic aggregation-induced emission (AIE) moieties as side chains and photothermal-responsive guest molecules (PTM), spontaneous sequential phase separation processes occur that lead to their controlled formation. Polymer-rich liquid droplets form first, f

SUBMITTER: Shao J 

PROVIDER: S-EPMC11897236 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature