TNMpBC-NeoBCSS model: a breast cancer specific survival prediction model for triple-negative metaplastic breast carcinoma patients with neoadjuvant therapy.

ABSTRACT: The breast cancer specific survival (BCSS) benefits of Neoadjuvant therapy (NeoAT) for triple-negative metaplastic breast cancer (TNMpBC) was uncertain. This study aimed to develop a prediction model for assessing the BCSS for TNMpBC patients with NeoAT. The primary cohort of 1163 patients with TNMpBC, from which a nomogram was established based on the results of a LASSO regression analysis, was derived from multi-centers data in China and the SEER database. This model was further validated by an independent cohort of 155 TNMpBC patients with NeoAT, with discrimination and calibration assessed. Totally 155 (13.3%) TNMpBC patients received NeoAT, with 45 (29.0%) cases demonstrating pathologic complete response (pCR), were enrolled. Subjects acquired pCR had superior BCSS. Four variables sig

SUBMITTER: Ni P 

PROVIDER: S-EPMC11897303 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature