Integrated microbiome and metabolomics analysis reveals the alleviating effect of <i>Pediococcus acidilactici</i> on colitis.

ABSTRACT: Colitis is a complicated disease caused by multiple factors, seriously threatening the host health and the development of animal husbandry. Probiotics have been demonstrate to participate in the active regulation of multiple gastrointestinal disease, gut microbiota and metabolism, but research on the efficacy of Pediococcus acidilactici isolated from dogs in alleviating colitis remains scarce. Here, we aimed to investigate the ameliorative effects of Pediococcus acidilactici isolated from dogs on colitis induced by LPS and its underlying molecular mechanisms. For this purpose, we collected colon contents from 15 mice for amplicon sequencing and metabolic analysis. Results showed that Pediococcus acidilactici could relieve the colon damage and cytokine disorder caused b

SUBMITTER: Wu L 

PROVIDER: S-EPMC11897304 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature