An exploratory study of high-throughput transcriptomic analysis reveals novel mRNA biomarkers for acute myocardial infarction using integrated methods.

ABSTRACT: Acute myocardial infarction (AMI) is a major contributor to cardiovascular-related mortality, and early diagnosis is crucial for effective treatment and better outcomes. While several biomarkers have been explored for AMI, there remains a need for reliable, non-invasive biomarkers that can accurately differentiate AMI patients from healthy individuals. This study aims to identify potential mRNA biomarkers in peripheral blood that could aid in the diagnosis and monitoring of AMI. We performed transcriptomic analysis of blood samples from 81 individuals, including 16 healthy controls, 58 AMI patients, and 7 post-treated AMI individuals. Through a combination of Sparse Partial Least Squares-Discriminant Analysis (sPLS-DA), random forest (RF), Weighted Gene Co-expression Network Analysis (WGCN

SUBMITTER: Huang F 

PROVIDER: S-EPMC11897311 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature