Dopaminergic modulation and dosage effects on brain state dynamics and working memory component processes in Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is primarily diagnosed through its characteristic motor deficits, yet it also encompasses progressive cognitive impairments that profoundly affect quality of life. While dopaminergic medications are routinely prescribed to manage motor symptoms in PD, their influence extends to cognitive functions as well. Here we investigate how dopaminergic medication influences aberrant brain circuit dynamics associated with encoding, maintenance and retrieval working memory (WM) task-phases processes. PD participants, both on and off dopaminergic medication, and healthy controls, performed a Sternberg WM task during fMRI scanning. We employ a Bayesian state-space computational model to delineate brain state dynamics related to different task phases. Importantly, a within-subjec

SUBMITTER: Lee B 

PROVIDER: S-EPMC11897313 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature