Choroidal thickness as predictor of subclinical carotid atherosclerosis in adults with type 1 diabetes.

ABSTRACT: Patients with Type 1 Diabetes (T1DM) have a higher risk of cardiovascular disease. This study used carotid ultrasound to identify subclinical carotid plaques and Optical Coherence Tomography (OCT) to evaluate ophthalmological markers as predictors of carotid plaque presence in 242 adults with T1DM, employing machine learning models for early risk assessment. Individuals with carotid plaques (N = 67) did not show significant differences in retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) and inner plexiform layer (IPL) complex compared to those without (N = 175). However, subfoveal and temporal choroidal area thickness significantly decreased in individuals with plaques (P ≤ 0.01). Machine learning identified age, hypertension, dyslipidemia, smoking, and diabetic retinopathy a

SUBMITTER: Castelblanco E 

PROVIDER: S-EPMC11897364 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature