Jellyfish: integrative visualization of spatio-temporal tumor evolution and clonal dynamics.

ABSTRACT:

Summary

Spatial and temporal intra-tumor heterogeneity drives tumor evolution and therapy resistance. Existing visualization tools often fail to capture both dimensions simultaneously. To address this, we developed Jellyfish, a tool that integrates phylogenetic and sample trees into a single plot, providing a holistic view of tumor evolution and capturing both spatial and temporal evolution. Available as a JavaScript library and R package, Jellyfish generates interactive visualizations from tumor phylogeny and clonal composition data. We demonstrate its ability to visualize complex subclonal dynamics using data from ovarian high-grade serous carcinoma.

Availability and implementation

Jellyfish is freely available with MIT license at https://github.com/HautaniemiLab/jellyfish

SUBMITTER: Lavikka K 

PROVIDER: S-EPMC11897425 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature