Antiepileptic drugs and foetal disorders: analysis of 20-year data from the pharmacovigilance center.

ABSTRACT:

Background

For women of childbearing age, the risks of uncontrolled epilepsy to the mother and fetus need to be balanced against the potential teratogenic effects of antiepileptic drugs (AEDs). The combined use of different types of AEDs has become a potential treatment option for the effective control of epileptic symptoms, while different studies present significant difference between the combined use of AEDs and foetal toxicity, which need a large comprehensive study to clarify the relation.

Objective

The study aims to analyze data from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) to explore the impact of monotherapy or polytherapy of AEDs on foetal and infant disorders.

Methods

Bayesian analysis and non-proportional methods we

SUBMITTER: Ji Z 

PROVIDER: S-EPMC11897480 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature