Vulnerability of the entorhinal cortex II to neurodegeneration in Alzheimer's disease.

ABSTRACT: Alzheimer's disease is characterized by progressive memory loss and deterioration of cognitive functions. The presence of neurofibrillary tangles in the hippocampal areas (perforant pathway) correlates with cognitive impairment. Pathological processing of tau protein is characterized by post-translational changes such as hyperphosphorylation and truncation, which favour conformational changes within tau. These conformational changes can be regional (dependent on phosphorylation) or structural (depending on regional conformational changes and truncation). Through immunohistochemical and immunofluorescence staining in hippocampus Alzheimer disease brains and quantification in tissue stained with TG3 antibody and analysed by confocal microscopy, we have been able to demonstrate that TG3 corre

SUBMITTER: Reyes-Pablo AE 

PROVIDER: S-EPMC11897590 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature