Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries.

ABSTRACT:

Importance

Age, sex, and apolipoprotein E (APOE) are the strongest risk factors for late-onset Alzheimer disease (AD). The role of APOE in AD varies with sex and ancestry. While the association of APOE with AD biomarkers also varies across sex and ancestry, no study has systematically investigated both sex-specific and ancestry differences of APOE on cerebrospinal fluid (CSF) biomarkers together, resulting in limited insights and generalizability.

Objective

To systematically investigate the association of sex and APOE-ε4 with 3 core CSF biomarkers across ancestries.

Design, setting, and participants

This cohort study examined 3 CSF biomarkers (amyloid β1-42 [Aβ42], phosphorylated tau 181 [p-tau], and total tau, in participants from 20 cohorts from July 1, 1985, to Mar

SUBMITTER: Xu X 

PROVIDER: S-EPMC11897841 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature