Loss of VSTM2A promotes adipocyte hypertrophy and disrupts metabolic homeostasis.

ABSTRACT:

Objective

Adipose tissue expands through hyperplasia and hypertrophy to store excess lipids, a process that is essential for the maintenance of metabolic homeostasis. The mechanisms regulating adipocyte recruitment from progenitors remain unclear. We have previously identified V-set and transmembrane domain-containing protein 2A (VSTM2A) as a factor promoting fat cell development in vitro. Whether VSTM2A impacts adipose tissue and systemic metabolism in vivo is still unknown.

Methods

We generated VSTM2A knockout mice (Vstm2a^-/-) using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) and fed them either a chow or high-fat diet. These mice were evaluated for body weight, adiposity, blood parameters, and glucose ho

SUBMITTER: Al Dow M 

PROVIDER: S-EPMC11897849 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature