Associations between decreases in adiposity and reductions in HbA1c and insulin use in the Look AHEAD cohort.

ABSTRACT:

Objective

The objective of this study was to elucidate associations between adiposity reduction and changes in HbA1c and insulin use among adults with type 2 diabetes and overweight or obesity.

Methods

Changes in BMI, waist circumference, and total percent fat mass were obtained over 8 years among 1316 individuals (aged 45-76 years) enrolled in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss. Generalized linear models were used to assess relationships between 5% decreases in adiposity measures with glycated hemoglobin (HbA1c) and insulin use over time.

Results

A 5% reduction in total percent fat was associated with 0.15% (95% CI: 0.12%-0.18%) lower mean HbA1c. Similarly, 5% reductions in waist circumference and BMI were also associated wit

SUBMITTER: Palmer R 

PROVIDER: S-EPMC11897852 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature