Tumor localization strategies of multicancer early detection tests: a quantitative assessment.

ABSTRACT:

Background

Multicancer early detection tests may expand cancer screening. Characterizing diagnostic resolution approaches following positive multicancer early detection tests is critical. Two trials employed distinct resolution approaches: a molecular signal to predict tissue of origin and an imaging-based diagnostic strategy. This modeling study characterizes diagnostic journeys and impact in a hypothetical population of average-risk multicancer early detection-eligible patients.

Methods

A mathematical expression for diagnostic burden was derived using positive predictive value (PPV), molecular tissue of origin localization accuracy, and numbers of procedures associated with each diagnostic outcome. Imaging-based and molecular tissue of origin-informed strategies were compa

SUBMITTER: Tyson C 

PROVIDER: S-EPMC11897890 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature