NABhClassifier Server: A Tool for the Identification of Helical Nucleic Acid-Binding Sequences in Proteins.

ABSTRACT: Engineered proteins capable of binding and transporting nucleic acids hold significant potential for advancing disease control in both the medical and agricultural fields. However, identifying small nucleic acid-binding domains remains challenging, as existing predictors primarily classify entire proteins as binders or nonbinders rather than targeting specific binding regions. Here, we introduce NABhClassifier, a highly efficient and precise web server designed to detect small helical sequences with nucleic acid-binding potential. Featuring an intuitive interface and a fully automated prediction pipeline, NABhClassifier integrates eight machine learning models for rapid analysis, delivering results in seconds per protein sequence. Predictions are summarized in the NABh index, a consensus s

SUBMITTER: Margis R 

PROVIDER: S-EPMC11898072 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature