Effects and Mechanisms of Imperatorin on Vitrified Mouse Oocytes.

ABSTRACT: Imperatorin (IMP) is a naturally occurring furanocoumarin with beneficial biological activities such as anticancer, antioxidant, and neuromodulatory properties. Currently, the protective effects and mechanisms of IMP on oxidative stress experienced by mouse oocytes after vitrification-thawing remain unclear. To investigate the influence of IMP on mouse oocyte development after vitrification-thawing, we added different concentrations of IMP to the vitrification and thawing media. Results indicated that the addition of 40 μM IMP enhanced post-thaw fertilization capacity, reduced intracellular reactive oxygen species (ROS) levels, and increased intracellular glutathione (GSH) levels. IMP also improved mitochondrial health by alleviating the decrease in mitochondrial membrane potential (MMP) a

SUBMITTER: Feng Y 

PROVIDER: S-EPMC11898152 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature