Efficacy of Lifting Threads Composed of Poly(L-Lactide-Co-ε-Caprolactone) Copolymers Coated With Hyaluronic Acid: A Long-Term Study on Biorevitalizing Properties in Skin Remodeling.

ABSTRACT:

Background

Facial thread lifting, which is popular in aesthetic medicine because of its minimal invasiveness, has led to advancements in the use of biodegradable polymers such as poly(L-lactide-co-ε-caprolactone) (P(LA/CL)) and its hyaluronic acid-coated variant (P(LA/CL)-HA). These developments enhance biocompatibility and efficacy, offering prolonged benefits through better biostimulation and tissue integration.

Methods

A controlled experiment involving five 4-month-old female pigs compared the effectiveness of P(LA/CL) and P(LA/CL)-HA threads over six months. After being implanted into the subcutaneous layer parallel to the skin of each pig, the threads were evaluated through histological analysis at intervals (7, 21, 30, 90, and 180 days) to assess changes in dermal and

SUBMITTER: Burko P 

PROVIDER: S-EPMC11898156 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature