Catalyst Activation and Speciation Involving DyadPalladate Precatalysts in Suzuki-Miyaura and Buchwald-Hartwig Cross-Couplings.

ABSTRACT: Understanding mechanisms underpinning Pd precatalyst activation and formation of active species is important in maximizing catalyst activity and lifetime. DyadPalladate precatalysts, represented by the general formula [R₃PH⁺]₂[Pd₂Cl₆]^2- (R₃P = tertiary alkylphosphine/arylphosphines), have recently emerged as sustainable, active Pd precatalysts for cross-couplings (e.g., Suzuki-Miyaura {SMCC} and Buchwald-Hartwig aryl amination {BHA}). This study investigates the activation of the [HXPhos]₂[Pd₂Cl₆] 1, as a model precatalyst from the DyadPalladate class, against BHA and SMCC reactions. It was found that BHA and SMCC reactions reached the same active Pd⁰ catalyst, [P

SUBMITTER: Scott NWJ 

PROVIDER: S-EPMC11898177 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature