Loneliness and Biomarkers of Alzheimer's Disease, Axonal Damage, and Astrogliosis: A Coordinated Analysis of Two Longitudinal Cohorts.

ABSTRACT:

Objectives

Loneliness is associated with an elevated risk of dementia. There is mixed evidence from imaging studies on whether loneliness is associated with neuropathology in dementia-free adults. This study tests whether loneliness is associated with plasma neurobiomarkers of amyloid (Aβ42/Aβ40), phosphorylated tau 181 (pTau181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) and imaging measures of amyloid and tau.

Methods

Participants were cognitively unimpaired older adults from the Baltimore Longitudinal Study on Aging (BLSA; N = 1,028 individuals and up to 2,277 neurobiomarker measurements; Baseline mean age = 66, SD = 15 years) and the UK Biobank (N = 1,263 individuals and up to 2,526 neurobiomarker measurements; Baseline mean age = 60, SD

SUBMITTER: Terracciano A 

PROVIDER: S-EPMC11898208 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature