NAE1-mediated neddylation coordinates ubiquitination regulation of meiotic recombination during spermatogenesis.

ABSTRACT: Rationale: Meiotic homologous recombination is a critical event in gametogenesis, which is tightly regulated to ensure the generation of crossovers on homologous chromosomes. This process is crucial for ensuring the accurate segregation of genetic material and maintaining genetic diversity within species, ultimately contributing to reproductive success. Nevertheless, comprehensive mechanisms of post-translational modification (PTM) regulating homologous recombination during meiosis require further investigation. The aim of this study is to investigate the regulatory mechanisms and physiological functions of NAE1-mediated neddylation during meiosis of mammalian spermatogenesis and its consequential role in infertility. Methods: The dynamic localization of NAE1 at various sub-s

SUBMITTER: Xi Y 

PROVIDER: S-EPMC11898277 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature