7-nm Mn_0.5 Zn_0.5Fe₂O₄ superparamagnetic iron oxide nanoparticle (SPION): a high-performance theranostic for MRI and hyperthermia applications.

ABSTRACT: Superparamagnetic iron oxide nanoparticles (SPIONs) are promising contrast agents for imaging-guided cancer therapies. However, challenges such as the requirement for a high alternating magnetic field (AMF), dosage limitations, and suboptimal imaging contrast have hindered their practical applications. Methods: First, the optimal doping ratio of Mn and Zn in Mn_xZn_1-xFe₂O₄ nanoparticles synthesized using a modified high-temperature thermal decomposition method (mHTTD) was determined. Then, the magnetic and physical properties of the optimal 7-nm Mn_0.5Zn_0.5Fe₂O₄ SPIONs were systematically and comprehensively characterized via hysteresis measurements, dynamic light scattering (DLS), transmission ele

SUBMITTER: Lee JY 

PROVIDER: S-EPMC11898280 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature