Bioeliminable Pt@Bi₂Se₃-RGD Nanoassembly for Enhancing Photoacoustic Imaging-Guided Tumor Immuno-Radiotherapy by Inducing Apoptosis via the Areg Pathway.

ABSTRACT: Background: Nanoradiosensitizers containing high Z-group elements have been reported widely as potential candidates for radiotherapy. However, the specific regulatory mechanism is unclear, and biodegradability needs to be addressed urgently. Methods: We synthesized a silk sericin-containing nano assembly, Pt@Bi₂Se₃-RGD (PBR). PBR's antitumor and bioeliminable effects were demonstrated in 4T1 tumor cells in vitro and in vivo. The immuno-radiotherapy effects of PBR were evaluated using a bilateral tumor model. Results: Combining photoacoustic imaging-guided PBR with radiotherapy improved the efficiency of anti-PD-L1 treatment, eliciting a robust immune response. Importantly, silk sericin-containing PBR could respond to the local intrac

SUBMITTER: Tan H 

PROVIDER: S-EPMC11898289 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature