Carnitine Metabolite as a Potential Circulating Biomarker for Sarcopenia in Men.

ABSTRACT:

Backgruound

Sarcopenia, a multifactorial disorder involving metabolic disturbance, suggests potential for metabolite biomarkers. Carnitine (CN), essential for skeletal muscle energy metabolism, may be a candidate biomarker. We investigated whether CN metabolites are biomarkers for sarcopenia.

Methods

Associations between the CN metabolites identified from an animal model of sarcopenia and muscle cells and sarcopenia status were evaluated in men from an age-matched discovery (72 cases, 72 controls) and a validation (21 cases, 47 controls) cohort.

Results

An association between CN metabolites and sarcopenia showed in mouse and cell studies. In the discovery cohort, plasma C5-CN levels were lower in sarcopenic men (P=0.005). C5-CN levels in men tended to be associated wi

SUBMITTER: Seo JH 

PROVIDER: S-EPMC11898317 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature