Elevated Circulating Sclerostin Levels in Frail Older Adults: Implications beyond Bone Health.

ABSTRACT:

Backgruound

Sclerostin, initially recognized for its pivotal role in bone metabolism, has gained attention for its multifaceted impact on overall human health. However, its influence on frailty-a condition that best reflects biological age-has not been thoroughly investigated.

Methods

We collected blood samples from 244 older adults who underwent comprehensive geriatric assessments. Sclerostin levels were quantified using an enzyme-linked immunosorbent assay. Frailty was assessed using two validated approaches: the phenotypic model by Fried and the deficit accumulation frailty index (FI) by Rockwood.

Results

After controlling for sex, age, and body mass index, we found that serum sclerostin levels were significantly elevated in frail individuals compared to their robu

SUBMITTER: Baek JY 

PROVIDER: S-EPMC11898323 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature