Perioperative dynamic changes of systemic inflammatory response, gut injury, and hypoxemia in patients with acute type-A aortic dissection: an observational case-control study.

ABSTRACT:

Background

The details regarding the pathogenesis of hypoxemia in the presence of acute type-A aortic dissection (ATAAD) remains to be fully elucidated. In this study, we investigated the dynamic changes in systemic inflammatory response, gut injury, hypoxemia, and succinate levels in patients with ATAAD and their impact on perioperative hypoxemia.

Methods

We conducted a single-center, observational, case-control study that enrolled 18 patients with ATAAD who underwent emergency total arch repair (TAR) combined with frozen elephant trunk (FET) procedure under hypothermic lower-body circulatory arrest and antegrade cerebral perfusion. White blood cell (WBC) count, interleukin (IL)6, IL8, tumor necrosis factor α (TNFα), diamine oxidase (DAO), intestinal fatty-acid-binding prot

SUBMITTER: Li J 

PROVIDER: S-EPMC11898389 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature