Pain-Related White-Matter Changes Following Mild Traumatic Brain Injury: A Longitudinal Diffusion Tensor Imaging Pilot Study.

ABSTRACT: Background: This study used diffusion tensor imaging (DTI) to detect brain microstructural changes in participants with mild traumatic brain injury (mTBI) who experienced post-traumatic headaches, a common issue that affects quality of life and rehabilitation. Despite its prevalence, the mechanisms behind post-traumatic headache are not well understood. Methods: Participants were recruited from Level 1 trauma centers, and MRI scans, including T1-weighted anatomical imaging and DTI, were acquired 1 month post-injury. Advanced imaging techniques corrected artifacts and extracted diffusion tensor measures reflecting white-matter integrity. Pain sensitivity assays were collected at 1 and 6 months post-injury, including quantitative sensory testing and psychological assessments. <

SUBMITTER: Yang HC 

PROVIDER: S-EPMC11898438 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature