The Enhancer-Promoter-Mediated <i>Wnt8a</i> Transcription During Neurite Regrowth of Injured Cortical Neurons.

ABSTRACT: Brain injuries can result from accidents, warfare, sports injuries, or brain diseases. Identifying regeneration-associated genes (RAGs) during epigenome remodeling upon brain injury could have a significant impact on reducing neuronal death and subsequent neurodegeneration for patients with brain injury. We previously identified several WNT genes as RAGs involved in the neurite regrowth of injured cortical neurons. Among them, the expression of the Wnt8a gene increased most significantly during neurite regrowth, indicating its potential to promote neuronal regeneration. In this study, we investigated the regulatory mechanism of Wnt8a transcription. An algorithm was developed to predict the novel enhancer regions of candidate genes. By combining active enhancer marks, histone

SUBMITTER: Weng SH 

PROVIDER: S-EPMC11898497 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature