Multiclass Determination of 87 Mixed Veterinary Drugs, Pesticides and Mycotoxin Residues in Beef Muscle Samples by Ionic Liquid-Based Dispersive Liquid-Liquid Microextraction and Liquid Chromatography Tandem Mass Spectrometry.

ABSTRACT: A miniaturised, eco-friendly and efficient multiclass method for the simultaneous determination of 87 veterinary drugs, pesticides and mycotoxin residues in beef muscle samples by ionic liquid-based dispersive liquid-liquid microextraction (IL-DLLME) and liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed and validated according to Commission Implementing Regulation (EU) 2021/808 and ISO/IEC 17025: 2017. Under IL-DLLME optimum conditions, matrix calibration yielded a coefficient of determination (R²) ranging from 0.99942 to 0.99997. The limit of detection (LOD) and limit of quantification (LOQ) ranged from 0.93 to 23.78 µg kg^-1 and from 1.98 to 38.27 µg kg^-1, respectively. Recoveries ranged from 80.0 to 109.8% and the decision lim

SUBMITTER: Mookantsa SOS 

PROVIDER: S-EPMC11898575 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature